| Date | Home | Away | Result |
|---|---|---|---|
| 10/27/22 7:15 PM | Tampa Bay Buccaneers | Baltimore Ravens | 22-27 |
| 10/30/22 8:30 AM | Jacksonville Jaguars | Denver Broncos | 17-21 |
| 10/30/22 12:00 PM | Dallas Cowboys | Chicago Bears | 49-29 |
| 10/30/22 12:00 PM | Atlanta Falcons | Carolina Panthers | 37-34OT |
| 10/30/22 12:00 PM | New York Jets | New England Patriots | 17-22 |
| 10/30/22 12:00 PM | Detroit Lions | Miami Dolphins | 27-31 |
| 10/30/22 12:00 PM | Philadelphia Eagles | Pittsburgh Steelers | 35-13 |
| 10/30/22 12:00 PM | New Orleans Saints | Las Vegas Raiders | 24-0 |
| 10/30/22 12:00 PM | Minnesota Vikings | Arizona Cardinals | 34-26 |
| 10/30/22 3:05 PM | Houston Texans | Tennessee Titans | 10-17 |
| 10/30/22 3:25 PM | Indianapolis Colts | Washington Commanders | 16-17 |
| 10/30/22 3:25 PM | Seattle Seahawks | New York Giants | 27-13 |
| 10/30/22 3:25 PM | Los Angeles Rams | San Francisco 49ers | 14-31 |
| 10/30/22 7:20 PM | Buffalo Bills | Green Bay Packers | 27-17 |
| 10/31/22 7:15 PM | Cleveland Browns | Cincinnati Bengals | 32-13 |