| Date | Home | Away | Result |
|---|---|---|---|
| 10/20/22 7:15 PM | Arizona Cardinals | New Orleans Saints | 42-34 |
| 10/23/22 12:00 PM | Washington Commanders | Green Bay Packers | 23-21 |
| 10/23/22 12:00 PM | Baltimore Ravens | Cleveland Browns | 23-20 |
| 10/23/22 12:00 PM | Tennessee Titans | Indianapolis Colts | 19-10 |
| 10/23/22 12:00 PM | Dallas Cowboys | Detroit Lions | 24-6 |
| 10/23/22 12:00 PM | Carolina Panthers | Tampa Bay Buccaneers | 21-3 |
| 10/23/22 12:00 PM | Cincinnati Bengals | Atlanta Falcons | 35-17 |
| 10/23/22 12:00 PM | Jacksonville Jaguars | New York Giants | 17-23 |
| 10/23/22 3:05 PM | Las Vegas Raiders | Houston Texans | 38-20 |
| 10/23/22 3:05 PM | Denver Broncos | New York Jets | 9-16 |
| 10/23/22 3:25 PM | Los Angeles Chargers | Seattle Seahawks | 23-37 |
| 10/23/22 3:25 PM | San Francisco 49ers | Kansas City Chiefs | 23-44 |
| 10/23/22 7:20 PM | Miami Dolphins | Pittsburgh Steelers | 16-10 |
| 10/24/22 7:15 PM | New England Patriots | Chicago Bears | 14-33 |