| Date | Home | Away | Result |
|---|---|---|---|
| 10/13/22 7:15 PM | Chicago Bears | Washington Commanders | 7-12 |
| 10/16/22 12:00 PM | Pittsburgh Steelers | Tampa Bay Buccaneers | 20-18 |
| 10/16/22 12:00 PM | New Orleans Saints | Cincinnati Bengals | 26-30 |
| 10/16/22 12:00 PM | New York Giants | Baltimore Ravens | 24-20 |
| 10/16/22 12:00 PM | Green Bay Packers | New York Jets | 10-27 |
| 10/16/22 12:00 PM | Miami Dolphins | Minnesota Vikings | 16-24 |
| 10/16/22 12:00 PM | Indianapolis Colts | Jacksonville Jaguars | 34-27 |
| 10/16/22 12:00 PM | Atlanta Falcons | San Francisco 49ers | 28-14 |
| 10/16/22 12:00 PM | Cleveland Browns | New England Patriots | 15-38 |
| 10/16/22 3:05 PM | Seattle Seahawks | Arizona Cardinals | 19-9 |
| 10/16/22 3:05 PM | Los Angeles Rams | Carolina Panthers | 24-10 |
| 10/16/22 3:25 PM | Kansas City Chiefs | Buffalo Bills | 20-24 |
| 10/16/22 7:20 PM | Philadelphia Eagles | Dallas Cowboys | 26-17 |
| 10/17/22 7:15 PM | Los Angeles Chargers | Denver Broncos | 19-16OT |