| Date | Home | Away | Result |
|---|---|---|---|
| 10/6/22 7:15 PM | Denver Broncos | Indianapolis Colts | 9-12OT |
| 10/9/22 8:30 AM | Green Bay Packers | New York Giants | 22-27 |
| 10/9/22 12:00 PM | Buffalo Bills | Pittsburgh Steelers | 38-3 |
| 10/9/22 12:00 PM | Tampa Bay Buccaneers | Atlanta Falcons | 21-15 |
| 10/9/22 12:00 PM | Washington Commanders | Tennessee Titans | 17-21 |
| 10/9/22 12:00 PM | New Orleans Saints | Seattle Seahawks | 39-32 |
| 10/9/22 12:00 PM | New York Jets | Miami Dolphins | 40-17 |
| 10/9/22 12:00 PM | Cleveland Browns | Los Angeles Chargers | 28-30 |
| 10/9/22 12:00 PM | New England Patriots | Detroit Lions | 29-0 |
| 10/9/22 12:00 PM | Minnesota Vikings | Chicago Bears | 29-22 |
| 10/9/22 12:00 PM | Jacksonville Jaguars | Houston Texans | 6-13 |
| 10/9/22 3:05 PM | Carolina Panthers | San Francisco 49ers | 15-37 |
| 10/9/22 3:25 PM | Arizona Cardinals | Philadelphia Eagles | 17-20 |
| 10/9/22 3:25 PM | Los Angeles Rams | Dallas Cowboys | 10-22 |
| 10/9/22 7:20 PM | Baltimore Ravens | Cincinnati Bengals | 19-17 |
| 10/10/22 7:15 PM | Kansas City Chiefs | Las Vegas Raiders | 30-29 |