| Date | Home | Away | Result |
|---|---|---|---|
| 9/29/22 7:15 PM | Cincinnati Bengals | Miami Dolphins | 27-15 |
| 10/2/22 8:30 AM | New Orleans Saints | Minnesota Vikings | 25-28 |
| 10/2/22 12:00 PM | Houston Texans | Los Angeles Chargers | 24-34 |
| 10/2/22 12:00 PM | Indianapolis Colts | Tennessee Titans | 17-24 |
| 10/2/22 12:00 PM | Detroit Lions | Seattle Seahawks | 45-48 |
| 10/2/22 12:00 PM | Baltimore Ravens | Buffalo Bills | 20-23 |
| 10/2/22 12:00 PM | Dallas Cowboys | Washington Commanders | 25-10 |
| 10/2/22 12:00 PM | Atlanta Falcons | Cleveland Browns | 23-20 |
| 10/2/22 12:00 PM | New York Giants | Chicago Bears | 20-12 |
| 10/2/22 12:00 PM | Pittsburgh Steelers | New York Jets | 20-24 |
| 10/2/22 12:00 PM | Philadelphia Eagles | Jacksonville Jaguars | 29-21 |
| 10/2/22 3:05 PM | Carolina Panthers | Arizona Cardinals | 16-26 |
| 10/2/22 3:25 PM | Las Vegas Raiders | Denver Broncos | 32-23 |
| 10/2/22 3:25 PM | Green Bay Packers | New England Patriots | 27-24OT |
| 10/2/22 7:20 PM | Tampa Bay Buccaneers | Kansas City Chiefs | 31-41 |
| 10/3/22 7:15 PM | San Francisco 49ers | Los Angeles Rams | 24-9 |