| Date | Home | Away | Result |
|---|---|---|---|
| 9/22/22 7:15 PM | Cleveland Browns | Pittsburgh Steelers | 29-17 |
| 9/25/22 12:00 PM | Washington Commanders | Philadelphia Eagles | 8-24 |
| 9/25/22 12:00 PM | Tennessee Titans | Las Vegas Raiders | 24-22 |
| 9/25/22 12:00 PM | New England Patriots | Baltimore Ravens | 26-37 |
| 9/25/22 12:00 PM | New York Jets | Cincinnati Bengals | 12-27 |
| 9/25/22 12:00 PM | Carolina Panthers | New Orleans Saints | 22-14 |
| 9/25/22 12:00 PM | Minnesota Vikings | Detroit Lions | 28-24 |
| 9/25/22 12:00 PM | Miami Dolphins | Buffalo Bills | 21-19 |
| 9/25/22 12:00 PM | Indianapolis Colts | Kansas City Chiefs | 20-17 |
| 9/25/22 12:00 PM | Chicago Bears | Houston Texans | 23-20 |
| 9/25/22 3:05 PM | Los Angeles Chargers | Jacksonville Jaguars | 10-38 |
| 9/25/22 3:25 PM | Tampa Bay Buccaneers | Green Bay Packers | 12-14 |
| 9/25/22 3:25 PM | Seattle Seahawks | Atlanta Falcons | 23-27 |
| 9/25/22 3:25 PM | Arizona Cardinals | Los Angeles Rams | 12-20 |
| 9/25/22 7:20 PM | Denver Broncos | San Francisco 49ers | 11-10 |
| 9/26/22 7:15 PM | New York Giants | Dallas Cowboys | 16-23 |