| Date | Home | Away | Result |
|---|---|---|---|
| 9/15/22 7:15 PM | Kansas City Chiefs | Los Angeles Chargers | 27-24 |
| 9/18/22 12:00 PM | New York Giants | Carolina Panthers | 19-16 |
| 9/18/22 12:00 PM | Jacksonville Jaguars | Indianapolis Colts | 24-0 |
| 9/18/22 12:00 PM | Cleveland Browns | New York Jets | 30-31 |
| 9/18/22 12:00 PM | Detroit Lions | Washington Commanders | 36-27 |
| 9/18/22 12:00 PM | New Orleans Saints | Tampa Bay Buccaneers | 10-20 |
| 9/18/22 12:00 PM | Pittsburgh Steelers | New England Patriots | 14-17 |
| 9/18/22 12:00 PM | Baltimore Ravens | Miami Dolphins | 38-42 |
| 9/18/22 3:05 PM | San Francisco 49ers | Seattle Seahawks | 27-7 |
| 9/18/22 3:05 PM | Los Angeles Rams | Atlanta Falcons | 31-27 |
| 9/18/22 3:25 PM | Dallas Cowboys | Cincinnati Bengals | 20-17 |
| 9/18/22 3:25 PM | Denver Broncos | Houston Texans | 16-9 |
| 9/18/22 3:25 PM | Las Vegas Raiders | Arizona Cardinals | 23-29OT |
| 9/18/22 7:20 PM | Green Bay Packers | Chicago Bears | 27-10 |
| 9/19/22 6:15 PM | Buffalo Bills | Tennessee Titans | 41-7 |
| 9/19/22 7:30 PM | Philadelphia Eagles | Minnesota Vikings | 24-7 |