| Date | Home | Away | Result |
|---|---|---|---|
| 12/1/22 7:15 PM | New England Patriots | Buffalo Bills | 10-24 |
| 12/4/22 12:00 PM | Chicago Bears | Green Bay Packers | 19-28 |
| 12/4/22 12:00 PM | Houston Texans | Cleveland Browns | 14-27 |
| 12/4/22 12:00 PM | Baltimore Ravens | Denver Broncos | 10-9 |
| 12/4/22 12:00 PM | Detroit Lions | Jacksonville Jaguars | 40-14 |
| 12/4/22 12:00 PM | Atlanta Falcons | Pittsburgh Steelers | 16-19 |
| 12/4/22 12:00 PM | New York Giants | Washington Commanders | 20-20OT |
| 12/4/22 12:00 PM | Philadelphia Eagles | Tennessee Titans | 35-10 |
| 12/4/22 12:00 PM | Minnesota Vikings | New York Jets | 27-22 |
| 12/4/22 3:05 PM | Los Angeles Rams | Seattle Seahawks | 23-27 |
| 12/4/22 3:05 PM | San Francisco 49ers | Miami Dolphins | 33-17 |
| 12/4/22 3:25 PM | Cincinnati Bengals | Kansas City Chiefs | 27-24 |
| 12/4/22 3:25 PM | Las Vegas Raiders | Los Angeles Chargers | 27-20 |
| 12/4/22 7:20 PM | Dallas Cowboys | Indianapolis Colts | 54-19 |
| 12/5/22 7:15 PM | Tampa Bay Buccaneers | New Orleans Saints | 17-16 |