| Date | Home | Away | Result |
|---|---|---|---|
| 11/24/22 11:30 AM | Detroit Lions | Buffalo Bills | 25-28 |
| 11/24/22 3:30 PM | Dallas Cowboys | New York Giants | 28-20 |
| 11/24/22 7:20 PM | Minnesota Vikings | New England Patriots | 33-26 |
| 11/27/22 12:00 PM | New York Jets | Chicago Bears | 31-10 |
| 11/27/22 12:00 PM | Washington Commanders | Atlanta Falcons | 19-13 |
| 11/27/22 12:00 PM | Carolina Panthers | Denver Broncos | 23-10 |
| 11/27/22 12:00 PM | Jacksonville Jaguars | Baltimore Ravens | 28-27 |
| 11/27/22 12:00 PM | Miami Dolphins | Houston Texans | 30-15 |
| 11/27/22 12:00 PM | Cleveland Browns | Tampa Bay Buccaneers | 23-17OT |
| 11/27/22 12:00 PM | Tennessee Titans | Cincinnati Bengals | 16-20 |
| 11/27/22 3:05 PM | Seattle Seahawks | Las Vegas Raiders | 34-40OT |
| 11/27/22 3:05 PM | Arizona Cardinals | Los Angeles Chargers | 24-25 |
| 11/27/22 3:25 PM | Kansas City Chiefs | Los Angeles Rams | 26-10 |
| 11/27/22 3:25 PM | San Francisco 49ers | New Orleans Saints | 13-0 |
| 11/27/22 7:20 PM | Philadelphia Eagles | Green Bay Packers | 40-33 |
| 11/28/22 7:15 PM | Indianapolis Colts | Pittsburgh Steelers | 17-24 |