| Date | Home | Away | Result |
|---|---|---|---|
| 11/4/22 2:45 PM | Sheffield Wednesday | FC Morecambe | 2-0 |
| 11/4/22 2:55 PM | Hereford FC | FC Portsmouth | 1-3 |
| 11/5/22 7:00 AM | South Shields FC | Forest Green Rovers | 0-2 |
| 11/5/22 7:30 AM | Bradford City | Harrogate Town FC | 0-1 |
| 11/5/22 9:00 AM | Bolton Wanderers | Barnsley FC | 1-2 |
| 11/5/22 10:00 AM | Weymouth FC | AFC Wimbledon | 1-1 |
| 11/5/22 10:00 AM | AFC Fylde | FC Gillingham | 1-1 |
| 11/5/22 10:00 AM | Charlton Athletic | Coalville Town | 4-1 |
| 11/5/22 10:00 AM | Fleetwood Town | Oxford City | 3-1 |
| 11/5/22 10:00 AM | Ebbsfleet United | Halifax Town | 2-1 |
| 11/5/22 10:00 AM | Wycombe Wanderers | FC Walsall | 0-2 |
| 11/5/22 10:00 AM | Sutton United | Farnborough | 0-2 |
| 11/5/22 10:00 AM | Burton Albion | Needham Market | 2-0 |
| 11/5/22 10:00 AM | Doncaster Rovers | Kings Lynn FC | 0-1 |
| 11/5/22 10:00 AM | Crawley Town | Accrington Stanley | 1-4 |
| 11/5/22 10:00 AM | Chippenham Town | Lincoln City | 1-0 |
| 11/5/22 10:00 AM | Barrow FC | Mansfield Town | 0-1 |
| 11/5/22 10:00 AM | Carlisle United | Tranmere Rovers | 2-1 |
| 11/5/22 10:00 AM | Maidenhead Utd | Dagenham and Redbridge | 0-1 |
| 11/5/22 10:00 AM | Peterborough United | Salford City | 0-0 |
| 11/5/22 10:00 AM | Crewe Alexandra | Leyton Orient | 1-0 |
| 11/5/22 10:00 AM | Grimsby Town | Plymouth Argyle | 5-1 |
| 11/5/22 10:00 AM | Milton Keynes Dons FC | Taunton Town | 6-0 |
| 11/5/22 10:00 AM | FC Port Vale | Exeter City | 2-3 |
| 11/5/22 10:00 AM | Solihull Moors FC | Hartlepool United | 2-2 |
| 11/5/22 10:00 AM | FC Gateshead | Stevenage FC | 2-3 |
| 11/5/22 10:00 AM | Buxton FC | Merthyr Town | 2-0 |
| 11/5/22 10:00 AM | Bristol Rovers | FC Rochdale | 1-0 |
| 11/5/22 10:00 AM | Newport County | Colchester United | 2-0 |
| 11/5/22 10:00 AM | Boreham Wood | Eastleigh FC | 3-1 |
| 11/5/22 10:00 AM | Cheltenham Town | Alvechurch | 1-2 |
| 11/5/22 10:00 AM | FC Chesterfield | Northampton Town | 1-0 |
| 11/5/22 10:00 AM | FC Barnet | Chelmsford City | 1-1 |
| 11/5/22 10:00 AM | Stockport County | Swindon Town | 4-0 |
| 11/5/22 10:00 AM | Shrewsbury Town | York City | 2-1 |
| 11/6/22 6:30 AM | AFC Wrexham | Oldham Athletic | 3-0 |
| 11/6/22 8:00 AM | Curzon Ashton FC | Cambridge United | 0-0 |
| 11/6/22 9:00 AM | Torquay United | Derby County | 2-2 |
| 11/7/22 1:45 PM | Bracknell Town | Ipswich Town | 0-3 |
| 11/14/22 1:30 PM | Chelmsford City | FC Barnet | 0-1 |
| 11/15/22 1:45 PM | FC Gillingham | AFC Fylde | 1-0 |
| 11/15/22 1:45 PM | Hartlepool United | Solihull Moors FC | 5-4a.PSO |
| 11/15/22 1:45 PM | AFC Wimbledon | Weymouth FC | 3-1 |
| 11/15/22 1:45 PM | Cambridge United | Curzon Ashton FC | 4-2a.PSO |
| 11/15/22 1:45 PM | Derby County | Torquay United | 5-0 |
| 11/16/22 1:45 PM | Woking FC | Oxford United | 1-2 |
| 11/16/22 1:45 PM | Salford City | Peterborough United | 0-3 |