| Date | Home | Away | Result |
|---|---|---|---|
| 12/11/25 11:45 AM | FC Midtjylland | KRC Genk | 1-0 |
| 12/11/25 11:45 AM | PFC Ludogorets Razgrad | PAOK Saloniki | 3-3 |
| 12/11/25 11:45 AM | FC Utrecht | Nottingham Forest | 1-2 |
| 12/11/25 11:45 AM | Ferencvaros Budapest | Glasgow Rangers | 2-1 |
| 12/11/25 11:45 AM | Young Boys Bern | OSC Lille | 1-0 |
| 12/11/25 11:45 AM | VfB Stuttgart | Maccabi Tel Aviv | 4-1 |
| 12/11/25 11:45 AM | Dinamo Zagreb | Real Betis Sevilla | 1-3 |
| 12/11/25 11:45 AM | SK Sturm Graz | Red Star Belgrad | 0-1 |
| 12/11/25 11:45 AM | OGC Nice | Sporting Braga | 0-1 |
| 12/11/25 2:00 PM | FC Porto | Malmö FF | 2-1 |
| 12/11/25 2:00 PM | FC Basel | Aston Villa | 1-2 |
| 12/11/25 2:00 PM | Olympique Lyon | Go Ahead Eagles Deventer | 2-1 |
| 12/11/25 2:00 PM | Panathinaikos Athens | Viktoria Plzen | 0-0 |
| 12/11/25 2:00 PM | SC Freiburg | FC Red Bull Salzburg | 1-0 |
| 12/11/25 2:00 PM | FCSB Bukarest | Feyenoord Rotterdam | 4-3 |
| 12/11/25 2:00 PM | Celta Vigo | FC Bologna | 1-2 |
| 12/11/25 2:00 PM | Celtic Glasgow | AS Roma | 0-3 |
| 12/11/25 2:00 PM | Brann Bergen | Fenerbahce Istanbul | 0-4 |