| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 5/26/26 5:00 PM | LDU Quito | Always Ready | Group G | 3-2 |
| 5/26/26 5:00 PM | CA Lanus | Mirassol FC | Group G | 1-0 |
| 5/26/26 7:30 PM | Estudiantes de La Plata | Independiente Medellín | Group A | 1-0 |
| 5/26/26 7:30 PM | Club Nacional de Football | Coquimbo Unido | Group B | 1-0 |
| 5/26/26 7:30 PM | Universitario | Deportes Tolima | Group B | 0-0 |
| 5/26/26 7:30 PM | Flamengo | Cusco FC | Group A | 3-0 |
| 5/27/26 5:00 PM | Independiente del Valle | Rosario Central | Group H | 1-0 |
| 5/27/26 5:00 PM | Club Libertad | Universidad Central | Group H | 0-1 |
| 5/27/26 7:30 PM | Club Bolívar | Independiente Rivadavia | Group C | 1-3 |
| 5/27/26 7:30 PM | Corinthians | CA Platense | Group E | 0-2 |
| 5/27/26 7:30 PM | Club Atlético Peñarol | Union Santa Fe | Group E | 0-1 |
| 5/27/26 7:30 PM | Fluminense | Deportivo La Guaira | Group C | 3-1 |
| 5/28/26 5:00 PM | Club Cerro Porteno | Sporting Cristal | Group F | 2-0 |
| 5/28/26 5:00 PM | Palmeiras | Junior FC | Group F | 4-1 |
| 5/28/26 7:30 PM | Boca Juniors | Universidad Católica | Group D | 0-1 |
| 5/28/26 7:30 PM | Cruzeiro | Barcelona SC | Group D | 4-0 |