| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 5/19/26 5:00 PM | Coquimbo Unido | Deportes Tolima | Group B | 3-0 |
| 5/19/26 5:00 PM | Fluminense | Club Bolívar | Group C | 2-1 |
| 5/19/26 5:00 PM | Rosario Central | Universidad Central | Group H | 4-0 |
| 5/19/26 7:00 PM | Always Ready | Mirassol FC | Group G | 1-2 |
| 5/19/26 7:00 PM | Union Santa Fe | CA Platense | Group E | 2-1 |
| 5/19/26 7:30 PM | Boca Juniors | Cruzeiro | Group D | 1-1 |
| 5/19/26 9:00 PM | Independiente del Valle | Club Libertad | Group H | 4-1 |
| 5/20/26 5:00 PM | Club Nacional de Football | Universitario | Group B | 0-0 |
| 5/20/26 7:30 PM | Flamengo | Estudiantes de La Plata | Group A | 1-0 |
| 5/20/26 7:30 PM | Palmeiras | Club Cerro Porteno | Group F | 0-1 |
| 5/20/26 7:30 PM | LDU Quito | CA Lanus | Group G | 2-0 |
| 5/20/26 9:00 PM | Junior FC | Sporting Cristal | Group F | 3-2 |
| 5/20/26 9:00 PM | Cusco FC | Independiente Medellín | Group A | 2-3 |
| 5/21/26 5:00 PM | Deportivo La Guaira | Independiente Rivadavia | Group C | --- |
| 5/21/26 7:30 PM | Universidad Católica | Barcelona SC | Group D | --- |
| 5/21/26 7:30 PM | Club Atlético Peñarol | Corinthians | Group E | --- |