| Date | Home | Away | Result |
|---|---|---|---|
| 10/22/26 9:30 AM | Kairat Almaty | Panathinaikos Athens | 1-5 |
| 10/22/26 11:45 AM | FC Nordsjaelland | ZSKA Sofia | 2-2 |
| 10/22/26 11:45 AM | FK Jablonec | Brighton and Hove Albion | 0-0 |
| 10/22/26 11:45 AM | FC Getafe | FC Lugano | 2-5 |
| 10/22/26 11:45 AM | Trabzonspor | Heart of Midlothian | 2-0 |
| 10/22/26 11:45 AM | Red Star Belgrad | FC Copenhagen | 2-2 |
| 10/22/26 11:45 AM | FC Iberia 1999 | Mjaellby AIF | 1-1 |
| 10/22/26 11:45 AM | FK Kauno Zalgiris | Brann Bergen | 1-4 |
| 10/22/26 11:45 AM | Inter Escaldes | Universitatea Craiova | 1-3 |
| 10/22/26 11:45 AM | Pafos FC | Riga FC | 1-1 |
| 10/22/26 2:00 PM | Lincoln Red Imps FC | FC Twente Enschede | 1-4 |
| 10/22/26 2:00 PM | FK Borac | Kuopion PS | 2-0 |
| 10/22/26 2:00 PM | FC Midtjylland | Sint-Truidense VV | 0-1 |
| 10/22/26 2:00 PM | AS Monaco | SC Freiburg | 3-0 |
| 10/22/26 2:00 PM | Ajax Amsterdam | Atalanta Bergamo | 2-0 |
| 10/22/26 2:00 PM | Sporting Braga | KAA Gent | 2-0 |
| 10/22/26 2:00 PM | Aarhus GF | KF Egnatia | 1-1 |
| 10/22/26 2:00 PM | FC Thun | HNK Hajduk Split | 0-1 |