| Date | Home | Away | Result |
|---|---|---|---|
| 12/9/25 9:30 AM | Kairat Almaty | Olympiakos Piräus | 0-1 |
| 12/9/25 11:45 AM | FC Bayern Munich | Sporting Lisbon | 3-1 |
| 12/9/25 2:00 PM | AS Monaco | Galatasaray Istanbul | 1-0 |
| 12/9/25 2:00 PM | FC Barcelona | Eintracht Frankfurt | 2-1 |
| 12/9/25 2:00 PM | PSV Eindhoven | Atletico Madrid | 2-3 |
| 12/9/25 2:00 PM | Atalanta Bergamo | Chelsea FC | 2-1 |
| 12/9/25 2:00 PM | Tottenham Hotspur | Slavia Prag | 3-0 |
| 12/9/25 2:00 PM | Royale Union Saint-Gilloise | Olympique Marseille | 2-3 |
| 12/9/25 2:00 PM | Inter Milan | Liverpool FC | 0-1 |
| 12/10/25 11:45 AM | FC Villarreal | FC Copenhagen | 2-3 |
| 12/10/25 11:45 AM | Qarabag | Ajax Amsterdam | 2-4 |
| 12/10/25 2:00 PM | Athletic Bilbao | Paris St. Germain | 0-0 |
| 12/10/25 2:00 PM | Bayer 04 Leverkusen | Newcastle United | 2-2 |
| 12/10/25 2:00 PM | Borussia Dortmund | FK Bodö/Glimt | 2-2 |
| 12/10/25 2:00 PM | Club Brugge | Arsenal FC | 0-3 |
| 12/10/25 2:00 PM | Juventus Turin | Pafos FC | 2-0 |
| 12/10/25 2:00 PM | Real Madrid | Manchester City | 1-2 |
| 12/10/25 2:00 PM | Benfica Lisbon | SSC Napoli | 2-0 |