Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/2/21 2:00 PM | 12/2/21 2:00 PM | Ajax Amsterdam | Willem II Tilburg | 5-0 | 2 - 4 points |
| 12/3/21 1:00 PM | 12/3/21 1:00 PM | FC Groningen | PEC Zwolle | 1-1 | 2 - 4 points |
| 12/4/21 9:30 AM | 12/4/21 9:30 AM | PSV Eindhoven | FC Utrecht | 4-1 | 2 - 4 points |
| 12/4/21 11:45 AM | 12/4/21 11:45 AM | Cambuur-Leeuwarden | Vitesse Arnheim | 1-6 | 2 - 4 points |
| 12/4/21 2:00 PM | 12/4/21 2:00 PM | Heracles Almelo | SC Heerenveen | 0-1 | 2 - 4 points |
| 12/5/21 5:15 AM | 12/5/21 5:15 AM | RKC Waalwijk | NEC Nijmwegen | 2-1 | 2 - 4 points |
| 12/5/21 7:30 AM | 12/5/21 7:30 AM | Go Ahead Eagles Deventer | FC Twente Enschede | 1-2 | 2 - 4 points |
| 12/5/21 7:30 AM | 12/5/21 7:30 AM | AZ Alkmaar | Sparta Rotterdam | 3-1 | 2 - 4 points |
| 12/5/21 9:45 AM | 12/5/21 9:45 AM | Feyenoord Rotterdam | Fortuna Sittard | 5-0 | 2 - 4 points |