Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/9/21 1:00 PM | 4/9/21 1:00 PM | Vitesse Arnheim | ADO Den Haag | 0-0 | 2 - 4 points |
| 4/10/21 11:45 AM | 4/10/21 11:45 AM | Heracles Almelo | Willem II Tilburg | 4-0 | 2 - 4 points |
| 4/10/21 1:00 PM | 4/10/21 1:00 PM | Fortuna Sittard | FC Emmen | 1-3 | 2 - 4 points |
| 4/10/21 1:00 PM | 4/10/21 1:00 PM | AZ Alkmaar | Sparta Rotterdam | 2-0 | 2 - 4 points |
| 4/10/21 2:00 PM | 4/10/21 2:00 PM | PEC Zwolle | FC Twente Enschede | 1-0 | 2 - 4 points |
| 4/11/21 5:15 AM | 4/11/21 5:15 AM | FC Utrecht | Feyenoord Rotterdam | 1-2 | 2 - 4 points |
| 4/11/21 7:30 AM | 4/11/21 7:30 AM | VVV Venlo | PSV Eindhoven | 0-2 | 2 - 4 points |
| 4/11/21 7:30 AM | 4/11/21 7:30 AM | FC Groningen | SC Heerenveen | 0-2 | 2 - 4 points |
| 4/11/21 9:45 AM | 4/11/21 9:45 AM | RKC Waalwijk | Ajax Amsterdam | 0-1 | 2 - 4 points |