Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/1/22 9:30 AM | 10/1/22 9:30 AM | Cambuur-Leeuwarden | PSV Eindhoven | 3-0 | 2 - 4 points |
| 10/1/22 11:45 AM | 10/1/22 11:45 AM | FC Groningen | AZ Alkmaar | 1-4 | 2 - 4 points |
| 10/1/22 1:00 PM | 10/1/22 1:00 PM | Ajax Amsterdam | Go Ahead Eagles Deventer | 1-1 | 2 - 4 points |
| 10/1/22 2:00 PM | 10/1/22 2:00 PM | FC Twente Enschede | Vitesse Arnheim | 3-0 | 2 - 4 points |
| 10/2/22 5:15 AM | 10/2/22 5:15 AM | Fortuna Sittard | FC Volendam | --- | 2 - 4 points |
| 10/2/22 7:30 AM | 10/2/22 7:30 AM | Excelsior Rotterdam | FC Utrecht | --- | 2 - 4 points |
| 10/2/22 7:30 AM | 10/2/22 7:30 AM | NEC Nijmwegen | Feyenoord Rotterdam | --- | 2 - 4 points |
| 10/2/22 9:45 AM | 10/2/22 9:45 AM | RKC Waalwijk | Sparta Rotterdam | --- | 2 - 4 points |
| 10/2/22 1:00 PM | 10/2/22 1:00 PM | FC Emmen | SC Heerenveen | --- | 2 - 4 points |