Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/10/21 12:00 PM | 9/10/21 11:59 AM | SV Meppen | SC Freiburg II | 0-1 | 2 - 6 points |
| 9/11/21 7:00 AM | 9/11/21 6:59 AM | FC Würzburger Kickers | TSV Havelse | 0-0 | 2 - 6 points |
| 9/11/21 7:00 AM | 9/11/21 6:59 AM | Viktoria 1889 Berlin | SV Wehen Wiesbaden | 3-1 | 2 - 6 points |
| 9/11/21 7:00 AM | 9/11/21 6:59 AM | 1. FC Kaiserslautern | SV Waldhof Mannheim | 0-0 | 2 - 6 points |
| 9/11/21 7:00 AM | 9/11/21 6:59 AM | Borussia Dortmund II | 1. FC Magdeburg | 0-2 | 2 - 6 points |
| 9/11/21 7:00 AM | 9/11/21 6:59 AM | FSV Zwickau | SC Verl | 1-3 | 2 - 6 points |
| 9/11/21 7:00 AM | 9/11/21 6:59 AM | FC Viktoria Köln | 1. FC Saarbrücken | 0-0 | 2 - 6 points |
| 9/12/21 6:00 AM | 9/12/21 5:59 AM | Hallescher FC | TSV 1860 Munich | 1-1 | 2 - 6 points |
| 9/12/21 7:00 AM | 9/12/21 6:59 AM | Eintracht Braunschweig | VfL Osnabrück | 2-2 | 2 - 6 points |
| 9/13/21 12:00 PM | 9/13/21 11:59 AM | Türkgücü München | MSV Duisburg | 1-0 | 2 - 6 points |