Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/20/21 12:00 PM | 8/20/21 11:59 AM | Viktoria 1889 Berlin | Hallescher FC | 0-1 | 2 - 6 points |
| 8/21/21 7:00 AM | 8/21/21 6:59 AM | 1. FC Kaiserslautern | TSV 1860 Munich | 3-0 | 2 - 6 points |
| 8/21/21 7:00 AM | 8/21/21 6:59 AM | 1. FC Magdeburg | MSV Duisburg | 2-1 | 2 - 6 points |
| 8/21/21 7:00 AM | 8/21/21 6:59 AM | Eintracht Braunschweig | FSV Zwickau | 2-0 | 2 - 6 points |
| 8/21/21 7:00 AM | 8/21/21 6:59 AM | FC Viktoria Köln | SV Waldhof Mannheim | 2-3 | 2 - 6 points |
| 8/21/21 7:00 AM | 8/21/21 6:59 AM | SV Meppen | SC Verl | 2-0 | 2 - 6 points |
| 8/21/21 7:00 AM | 8/21/21 6:59 AM | Borussia Dortmund II | 1. FC Saarbrücken | 0-0 | 2 - 6 points |
| 8/22/21 6:00 AM | 8/22/21 5:59 AM | FC Würzburger Kickers | VfL Osnabrück | 1-1 | 2 - 6 points |
| 8/22/21 7:00 AM | 8/22/21 6:59 AM | SV Wehen Wiesbaden | TSV Havelse | 2-1 | 2 - 6 points |
| 8/22/21 8:00 AM | 8/22/21 7:59 AM | Türkgücü München | SC Freiburg II | 3-0 | 2 - 6 points |