Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/16/22 7:00 AM | 4/16/22 6:59 AM | FSV Zwickau | SV Wehen Wiesbaden | 2-1 | 2 - 6 points |
| 4/16/22 7:00 AM | 4/16/22 6:59 AM | SV Meppen | Borussia Dortmund II | 1-1 | 2 - 6 points |
| 4/16/22 7:00 AM | 4/16/22 6:59 AM | Eintracht Braunschweig | FC Würzburger Kickers | 1-0 | 2 - 6 points |
| 4/16/22 7:00 AM | 4/16/22 6:59 AM | TSV 1860 Munich | VfL Osnabrück | 2-3 | 2 - 6 points |
| 4/16/22 7:00 AM | 4/16/22 6:59 AM | Viktoria 1889 Berlin | MSV Duisburg | 0-1 | 2 - 6 points |
| 4/16/22 7:00 AM | 4/16/22 6:59 AM | Hallescher FC | TSV Havelse | 1-1 | 2 - 6 points |
| 4/17/22 6:00 AM | 4/17/22 5:59 AM | SC Verl | 1. FC Magdeburg | 4-5 | 2 - 6 points |
| 4/17/22 7:00 AM | 4/17/22 6:59 AM | 1. FC Kaiserslautern | 1. FC Saarbrücken | 3-1 | 2 - 6 points |
| 4/18/22 12:00 PM | 4/18/22 11:59 AM | SV Waldhof Mannheim | SC Freiburg II | 0-1 | 2 - 6 points |