Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/24/21 12:00 PM | 9/24/21 11:59 AM | Hallescher FC | 1. FC Magdeburg | 3-2 | 2 - 6 points |
| 9/25/21 7:00 AM | 9/25/21 6:59 AM | FC Viktoria Köln | MSV Duisburg | 4-2 | 2 - 6 points |
| 9/25/21 7:00 AM | 9/25/21 6:59 AM | FC Würzburger Kickers | SV Wehen Wiesbaden | 0-4 | 2 - 6 points |
| 9/25/21 7:00 AM | 9/25/21 6:59 AM | Eintracht Braunschweig | SV Waldhof Mannheim | 0-0 | 2 - 6 points |
| 9/25/21 7:00 AM | 9/25/21 6:59 AM | 1. FC Kaiserslautern | VfL Osnabrück | 2-0 | 2 - 6 points |
| 9/25/21 7:00 AM | 9/25/21 6:59 AM | SV Meppen | 1. FC Saarbrücken | 2-2 | 2 - 6 points |
| 9/25/21 7:00 AM | 9/25/21 6:59 AM | SC Verl | TSV 1860 Munich | 1-1 | 2 - 6 points |
| 9/26/21 6:00 AM | 9/26/21 5:59 AM | Türkgücü München | Borussia Dortmund II | 2-1 | 2 - 6 points |
| 9/26/21 7:00 AM | 9/26/21 6:59 AM | FSV Zwickau | SC Freiburg II | 0-0 | 2 - 6 points |
| 9/27/21 12:00 PM | 9/27/21 11:59 AM | Viktoria 1889 Berlin | TSV Havelse | 3-4 | 2 - 6 points |