| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/16/22 8:30 AM | 4/16/22 8:30 AM | FC Augsburg | Hertha BSC | 0-1 | 3 - 5 points |
| 4/16/22 8:30 AM | 4/16/22 8:30 AM | FSV Mainz 05 | VfB Stuttgart | 0-0 | 3 - 5 points |
| 4/16/22 8:30 AM | 4/16/22 8:30 AM | SC Freiburg | VfL Bochum | 3-0 | 3 - 5 points |
| 4/16/22 8:30 AM | 4/16/22 8:30 AM | Borussia Dortmund | VfL Wolfsburg | 6-1 | 3 - 5 points |
| 4/16/22 11:30 AM | 4/16/22 11:30 AM | Bor. Mönchengladbach | 1. FC Köln | 1-3 | 3 - 5 points |
| 4/17/22 8:30 AM | 4/17/22 8:30 AM | Arminia Bielefeld | FC Bayern Munich | 0-3 | 3 - 5 points |
| 4/17/22 10:30 AM | 4/17/22 10:30 AM | 1899 Hoffenheim | SpVgg Greuther Fürth | 0-0 | 3 - 5 points |
| 4/17/22 10:30 AM | 4/17/22 10:30 AM | 1. FC Union Berlin | Eintracht Frankfurt | 2-0 | 3 - 5 points |
| 4/17/22 12:30 PM | 4/17/22 12:30 PM | Bayer 04 Leverkusen | RB Leipzig | 0-1 | 3 - 5 points |