Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/1/21 11:30 AM | 10/1/21 11:30 AM | Werder Bremen | 1. FC Heidenheim 1846 | 3-0 | 2 - 4 points |
| 10/1/21 11:30 AM | 10/1/21 11:30 AM | Erzgebirge Aue | Hamburger SV | 1-1 | 2 - 4 points |
| 10/2/21 6:30 AM | 10/2/21 6:30 AM | Holstein Kiel | FC Hansa Rostock | 0-2 | 2 - 4 points |
| 10/2/21 6:30 AM | 10/2/21 6:30 AM | Fortuna Düsseldorf | SC Paderborn 07 | 2-3 | 2 - 4 points |
| 10/2/21 6:30 AM | 10/2/21 6:30 AM | Jahn Regensburg | Karlsruher SC | 2-2 | 2 - 4 points |
| 10/2/21 1:30 PM | 10/2/21 1:30 PM | 1. FC Nürnberg | Hannover 96 | 0-0 | 2 - 4 points |
| 10/3/21 6:30 AM | 10/3/21 6:30 AM | SV Sandhausen | SV Darmstadt 98 | 1-6 | 2 - 4 points |
| 10/3/21 6:30 AM | 10/3/21 6:30 AM | FC Schalke 04 | FC Ingolstadt | 3-0 | 2 - 4 points |
| 10/3/21 6:30 AM | 10/3/21 6:30 AM | FC St. Pauli | Dynamo Dresden | 3-0 | 2 - 4 points |