Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/24/21 11:30 AM | 9/24/21 11:30 AM | 1. FC Heidenheim 1846 | SV Darmstadt 98 | 2-1 | 2 - 4 points |
| 9/24/21 11:30 AM | 9/24/21 11:30 AM | Jahn Regensburg | Erzgebirge Aue | 3-2 | 2 - 4 points |
| 9/25/21 6:30 AM | 9/25/21 6:30 AM | Karlsruher SC | FC St. Pauli | 1-3 | 2 - 4 points |
| 9/25/21 6:30 AM | 9/25/21 6:30 AM | SC Paderborn 07 | Holstein Kiel | 1-2 | 2 - 4 points |
| 9/25/21 6:30 AM | 9/25/21 6:30 AM | FC Ingolstadt | Fortuna Düsseldorf | 1-2 | 2 - 4 points |
| 9/25/21 1:30 PM | 9/25/21 1:30 PM | FC Hansa Rostock | FC Schalke 04 | 0-2 | 2 - 4 points |
| 9/26/21 6:30 AM | 9/26/21 6:30 AM | Hannover 96 | SV Sandhausen | 1-2 | 2 - 4 points |
| 9/26/21 6:30 AM | 9/26/21 6:30 AM | Dynamo Dresden | Werder Bremen | 3-0 | 2 - 4 points |
| 9/26/21 6:30 AM | 9/26/21 6:30 AM | Hamburger SV | 1. FC Nürnberg | 2-2 | 2 - 4 points |