Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/17/21 11:30 AM | 9/17/21 11:30 AM | 1. FC Nürnberg | FC Hansa Rostock | 1-0 | 2 - 4 points |
| 9/17/21 11:30 AM | 9/17/21 11:30 AM | FC Schalke 04 | Karlsruher SC | 1-2 | 2 - 4 points |
| 9/18/21 6:30 AM | 9/18/21 6:30 AM | Fortuna Düsseldorf | Jahn Regensburg | 1-1 | 2 - 4 points |
| 9/18/21 6:30 AM | 9/18/21 6:30 AM | SV Sandhausen | 1. FC Heidenheim 1846 | 1-3 | 2 - 4 points |
| 9/18/21 6:30 AM | 9/18/21 6:30 AM | Holstein Kiel | Hannover 96 | 0-3 | 2 - 4 points |
| 9/18/21 1:30 PM | 9/18/21 1:30 PM | Werder Bremen | Hamburger SV | 0-2 | 2 - 4 points |
| 9/19/21 6:30 AM | 9/19/21 6:30 AM | SV Darmstadt 98 | Dynamo Dresden | 1-0 | 2 - 4 points |
| 9/19/21 6:30 AM | 9/19/21 6:30 AM | FC St. Pauli | FC Ingolstadt | 4-1 | 2 - 4 points |
| 9/19/21 6:30 AM | 9/19/21 6:30 AM | Erzgebirge Aue | SC Paderborn 07 | 1-4 | 2 - 4 points |