Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/20/21 11:30 AM | 8/20/21 11:30 AM | Fortuna Düsseldorf | Holstein Kiel | 2-2 | 2 - 4 points |
| 8/20/21 11:30 AM | 8/20/21 11:30 AM | Hannover 96 | 1. FC Heidenheim 1846 | 1-0 | 2 - 4 points |
| 8/21/21 6:30 AM | 8/21/21 6:30 AM | Karlsruher SC | Werder Bremen | 0-0 | 2 - 4 points |
| 8/21/21 6:30 AM | 8/21/21 6:30 AM | SC Paderborn 07 | FC St. Pauli | 3-1 | 2 - 4 points |
| 8/21/21 6:30 AM | 8/21/21 6:30 AM | Jahn Regensburg | FC Schalke 04 | 4-1 | 2 - 4 points |
| 8/21/21 1:30 PM | 8/21/21 1:30 PM | FC Hansa Rostock | Dynamo Dresden | 1-3 | 2 - 4 points |
| 8/22/21 6:30 AM | 8/22/21 6:30 AM | Erzgebirge Aue | SV Sandhausen | 1-3 | 2 - 4 points |
| 8/22/21 6:30 AM | 8/22/21 6:30 AM | FC Ingolstadt | 1. FC Nürnberg | 0-0 | 2 - 4 points |
| 8/22/21 6:30 AM | 8/22/21 6:30 AM | Hamburger SV | SV Darmstadt 98 | 2-2 | 2 - 4 points |