Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/29/22 11:30 AM | 4/29/22 11:30 AM | 1. FC Heidenheim 1846 | Fortuna Düsseldorf | 1-3 | 2 - 4 points |
| 4/29/22 11:30 AM | 4/29/22 11:30 AM | FC St. Pauli | 1. FC Nürnberg | 1-1 | 2 - 4 points |
| 4/29/22 11:30 AM | 4/29/22 11:30 AM | Hannover 96 | Karlsruher SC | 2-0 | 2 - 4 points |
| 4/29/22 11:30 AM | 4/29/22 11:30 AM | SV Sandhausen | FC Schalke 04 | 1-2 | 2 - 4 points |
| 4/29/22 11:30 AM | 4/29/22 11:30 AM | Werder Bremen | Holstein Kiel | 2-3 | 2 - 4 points |
| 4/30/22 6:30 AM | 4/30/22 6:30 AM | Dynamo Dresden | Jahn Regensburg | 1-1 | 2 - 4 points |
| 4/30/22 6:30 AM | 4/30/22 6:30 AM | FC Hansa Rostock | SC Paderborn 07 | 0-0 | 2 - 4 points |
| 4/30/22 6:30 AM | 4/30/22 6:30 AM | FC Ingolstadt | Hamburger SV | 0-4 | 2 - 4 points |
| 4/30/22 1:30 PM | 4/30/22 1:30 PM | SV Darmstadt 98 | Erzgebirge Aue | 6-0 | 2 - 4 points |