Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/16/22 6:30 AM | 4/16/22 6:30 AM | Hannover 96 | Fortuna Düsseldorf | 0-0 | 2 - 4 points |
| 4/16/22 6:30 AM | 4/16/22 6:30 AM | SV Sandhausen | FC St. Pauli | 1-1 | 2 - 4 points |
| 4/16/22 6:30 AM | 4/16/22 6:30 AM | Dynamo Dresden | Holstein Kiel | 0-0 | 2 - 4 points |
| 4/16/22 1:30 PM | 4/16/22 1:30 PM | Hamburger SV | Karlsruher SC | 3-0 | 2 - 4 points |
| 4/17/22 6:30 AM | 4/17/22 6:30 AM | FC Hansa Rostock | Jahn Regensburg | 1-1 | 2 - 4 points |
| 4/17/22 6:30 AM | 4/17/22 6:30 AM | FC Ingolstadt | SC Paderborn 07 | 0-1 | 2 - 4 points |
| 4/17/22 6:30 AM | 4/17/22 6:30 AM | Werder Bremen | 1. FC Nürnberg | 1-1 | 2 - 4 points |
| 4/17/22 6:30 AM | 4/17/22 6:30 AM | SV Darmstadt 98 | FC Schalke 04 | 2-5 | 2 - 4 points |
| 4/17/22 6:30 AM | 4/17/22 6:30 AM | 1. FC Heidenheim 1846 | Erzgebirge Aue | 0-2 | 2 - 4 points |