Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/8/22 11:30 AM | 4/8/22 11:30 AM | Jahn Regensburg | FC Ingolstadt | 1-1 | 2 - 4 points |
| 4/8/22 11:30 AM | 4/8/22 11:30 AM | Fortuna Düsseldorf | FC Hansa Rostock | 3-0 | 2 - 4 points |
| 4/9/22 6:30 AM | 4/9/22 6:30 AM | Erzgebirge Aue | Hannover 96 | 1-3 | 2 - 4 points |
| 4/9/22 6:30 AM | 4/9/22 6:30 AM | FC Schalke 04 | 1. FC Heidenheim 1846 | 3-0 | 2 - 4 points |
| 4/9/22 6:30 AM | 4/9/22 6:30 AM | FC St. Pauli | Werder Bremen | 1-1 | 2 - 4 points |
| 4/9/22 1:30 PM | 4/9/22 1:30 PM | 1. FC Nürnberg | SV Darmstadt 98 | 3-1 | 2 - 4 points |
| 4/10/22 6:30 AM | 4/10/22 6:30 AM | SV Sandhausen | Dynamo Dresden | 2-1 | 2 - 4 points |
| 4/10/22 6:30 AM | 4/10/22 6:30 AM | Holstein Kiel | Hamburger SV | 1-0 | 2 - 4 points |
| 4/10/22 6:30 AM | 4/10/22 6:30 AM | SC Paderborn 07 | Karlsruher SC | 2-2 | 2 - 4 points |