Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 2/25/22 11:30 AM | 2/25/22 11:30 AM | Hannover 96 | Holstein Kiel | 2-0 | 2 - 4 points |
| 2/25/22 11:30 AM | 2/25/22 11:30 AM | SC Paderborn 07 | Erzgebirge Aue | 3-3 | 2 - 4 points |
| 2/26/22 6:30 AM | 2/26/22 6:30 AM | FC Hansa Rostock | 1. FC Nürnberg | 0-2 | 2 - 4 points |
| 2/26/22 6:30 AM | 2/26/22 6:30 AM | FC Ingolstadt | FC St. Pauli | 1-3 | 2 - 4 points |
| 2/26/22 6:30 AM | 2/26/22 6:30 AM | Karlsruher SC | FC Schalke 04 | 1-1 | 2 - 4 points |
| 2/26/22 1:30 PM | 2/26/22 1:30 PM | Dynamo Dresden | SV Darmstadt 98 | 0-1 | 2 - 4 points |
| 2/27/22 6:30 AM | 2/27/22 6:30 AM | Jahn Regensburg | Fortuna Düsseldorf | 0-0 | 2 - 4 points |
| 2/27/22 6:30 AM | 2/27/22 6:30 AM | Hamburger SV | Werder Bremen | 2-3 | 2 - 4 points |
| 2/27/22 6:30 AM | 2/27/22 6:30 AM | 1. FC Heidenheim 1846 | SV Sandhausen | 1-1 | 2 - 4 points |