Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 2/18/22 11:30 AM | 2/18/22 11:30 AM | Dynamo Dresden | 1. FC Heidenheim 1846 | 1-1 | 2 - 4 points |
| 2/18/22 11:30 AM | 2/18/22 11:30 AM | FC Schalke 04 | SC Paderborn 07 | 2-0 | 2 - 4 points |
| 2/19/22 6:30 AM | 2/19/22 6:30 AM | Werder Bremen | FC Ingolstadt | 1-1 | 2 - 4 points |
| 2/19/22 6:30 AM | 2/19/22 6:30 AM | Holstein Kiel | Karlsruher SC | 0-2 | 2 - 4 points |
| 2/19/22 6:30 AM | 2/19/22 6:30 AM | SV Sandhausen | Hamburger SV | 1-1 | 2 - 4 points |
| 2/19/22 1:30 PM | 2/19/22 1:30 PM | 1. FC Nürnberg | Jahn Regensburg | 2-0 | 2 - 4 points |
| 2/20/22 6:30 AM | 2/20/22 6:30 AM | Fortuna Düsseldorf | Erzgebirge Aue | 3-1 | 2 - 4 points |
| 2/20/22 6:30 AM | 2/20/22 6:30 AM | SV Darmstadt 98 | FC Hansa Rostock | 1-1 | 2 - 4 points |
| 2/20/22 6:30 AM | 2/20/22 6:30 AM | FC St. Pauli | Hannover 96 | 0-3 | 2 - 4 points |