Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 2/4/22 11:30 AM | 2/4/22 11:30 AM | 1. FC Heidenheim 1846 | Hannover 96 | 3-1 | 2 - 4 points |
| 2/4/22 11:30 AM | 2/4/22 11:30 AM | 1. FC Nürnberg | FC Ingolstadt | 0-5 | 2 - 4 points |
| 2/5/22 6:30 AM | 2/5/22 6:30 AM | SV Sandhausen | Erzgebirge Aue | 2-0 | 2 - 4 points |
| 2/5/22 6:30 AM | 2/5/22 6:30 AM | Werder Bremen | Karlsruher SC | 2-1 | 2 - 4 points |
| 2/5/22 6:30 AM | 2/5/22 6:30 AM | FC Schalke 04 | Jahn Regensburg | 2-1 | 2 - 4 points |
| 2/5/22 1:30 PM | 2/5/22 1:30 PM | FC St. Pauli | SC Paderborn 07 | 2-2 | 2 - 4 points |
| 2/6/22 6:30 AM | 2/6/22 6:30 AM | SV Darmstadt 98 | Hamburger SV | 0-5 | 2 - 4 points |
| 2/6/22 6:30 AM | 2/6/22 6:30 AM | Dynamo Dresden | FC Hansa Rostock | 1-4 | 2 - 4 points |
| 2/6/22 6:30 AM | 2/6/22 6:30 AM | Holstein Kiel | Fortuna Düsseldorf | 1-0 | 2 - 4 points |