Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 7/30/21 11:30 AM | 7/30/21 11:30 AM | SC Paderborn 07 | 1. FC Nürnberg | 2-2 | 2 - 4 points |
| 7/30/21 11:30 AM | 7/30/21 11:30 AM | Karlsruher SC | SV Darmstadt 98 | 3-0 | 2 - 4 points |
| 7/31/21 6:30 AM | 7/31/21 6:30 AM | Hannover 96 | FC Hansa Rostock | 0-3 | 2 - 4 points |
| 7/31/21 6:30 AM | 7/31/21 6:30 AM | Jahn Regensburg | SV Sandhausen | 3-0 | 2 - 4 points |
| 7/31/21 6:30 AM | 7/31/21 6:30 AM | FC Ingolstadt | 1. FC Heidenheim 1846 | 1-2 | 2 - 4 points |
| 7/31/21 1:30 PM | 7/31/21 1:30 PM | Fortuna Düsseldorf | Werder Bremen | 2-3 | 2 - 4 points |
| 8/1/21 6:30 AM | 8/1/21 6:30 AM | Erzgebirge Aue | FC St. Pauli | 0-0 | 2 - 4 points |
| 8/1/21 6:30 AM | 8/1/21 6:30 AM | Holstein Kiel | FC Schalke 04 | 0-3 | 2 - 4 points |
| 8/1/21 6:30 AM | 8/1/21 6:30 AM | Hamburger SV | Dynamo Dresden | 1-1 | 2 - 4 points |