Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/17/21 11:30 AM | 12/17/21 11:30 AM | Fortuna Düsseldorf | SV Sandhausen | 0-1 | 2 - 4 points |
| 12/17/21 11:30 AM | 12/17/21 11:30 AM | Holstein Kiel | FC St. Pauli | 3-0 | 2 - 4 points |
| 12/18/21 6:30 AM | 12/18/21 6:30 AM | SC Paderborn 07 | 1. FC Heidenheim 1846 | 1-2 | 2 - 4 points |
| 12/18/21 6:30 AM | 12/18/21 6:30 AM | Erzgebirge Aue | 1. FC Nürnberg | 1-3 | 2 - 4 points |
| 12/18/21 6:30 AM | 12/18/21 6:30 AM | FC Ingolstadt | Dynamo Dresden | 3-0 | 2 - 4 points |
| 12/18/21 1:30 PM | 12/18/21 1:30 PM | Hamburger SV | FC Schalke 04 | 1-1 | 2 - 4 points |
| 12/19/21 6:30 AM | 12/19/21 6:30 AM | Karlsruher SC | FC Hansa Rostock | 2-2 | 2 - 4 points |
| 12/19/21 6:30 AM | 12/19/21 6:30 AM | Hannover 96 | Werder Bremen | 1-4 | 2 - 4 points |
| 12/19/21 6:30 AM | 12/19/21 6:30 AM | Jahn Regensburg | SV Darmstadt 98 | 0-2 | 2 - 4 points |