Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/10/21 11:30 AM | 12/10/21 11:30 AM | FC Schalke 04 | 1. FC Nürnberg | 4-1 | 2 - 4 points |
| 12/10/21 11:30 AM | 12/10/21 11:30 AM | Jahn Regensburg | Werder Bremen | 2-3 | 2 - 4 points |
| 12/11/21 6:30 AM | 12/11/21 6:30 AM | Holstein Kiel | SV Sandhausen | 2-2 | 2 - 4 points |
| 12/11/21 6:30 AM | 12/11/21 6:30 AM | SC Paderborn 07 | SV Darmstadt 98 | 0-1 | 2 - 4 points |
| 12/11/21 6:30 AM | 12/11/21 6:30 AM | FC Ingolstadt | Hannover 96 | 1-2 | 2 - 4 points |
| 12/11/21 1:30 PM | 12/11/21 1:30 PM | Fortuna Düsseldorf | FC St. Pauli | 1-1 | 2 - 4 points |
| 12/12/21 6:30 AM | 12/12/21 6:30 AM | Hamburger SV | FC Hansa Rostock | 3-0 | 2 - 4 points |
| 12/12/21 6:30 AM | 12/12/21 6:30 AM | Karlsruher SC | 1. FC Heidenheim 1846 | 3-2 | 2 - 4 points |
| 12/12/21 6:30 AM | 12/12/21 6:30 AM | Erzgebirge Aue | Dynamo Dresden | 0-1 | 2 - 4 points |