Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/19/21 11:30 AM | 11/19/21 11:30 AM | Hannover 96 | SC Paderborn 07 | 0-0 | 2 - 4 points |
| 11/19/21 11:30 AM | 11/19/21 11:30 AM | SV Sandhausen | 1. FC Nürnberg | 1-2 | 2 - 4 points |
| 11/20/21 6:30 AM | 11/20/21 6:30 AM | FC Hansa Rostock | Erzgebirge Aue | 1-2 | 2 - 4 points |
| 11/20/21 6:30 AM | 11/20/21 6:30 AM | Hamburger SV | Jahn Regensburg | 4-1 | 2 - 4 points |
| 11/20/21 6:30 AM | 11/20/21 6:30 AM | SV Darmstadt 98 | FC St. Pauli | 4-0 | 2 - 4 points |
| 11/20/21 1:30 PM | 11/20/21 1:30 PM | Werder Bremen | FC Schalke 04 | 1-1 | 2 - 4 points |
| 11/21/21 6:30 AM | 11/21/21 6:30 AM | FC Ingolstadt | Karlsruher SC | 1-1 | 2 - 4 points |
| 11/21/21 6:30 AM | 11/21/21 6:30 AM | 1. FC Heidenheim 1846 | Holstein Kiel | 2-1 | 2 - 4 points |
| 11/21/21 6:30 AM | 11/21/21 6:30 AM | Dynamo Dresden | Fortuna Düsseldorf | 1-0 | 2 - 4 points |