Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/22/21 11:30 AM | 10/22/21 11:30 AM | Erzgebirge Aue | FC Ingolstadt | 1-0 | 2 - 4 points |
| 10/22/21 11:30 AM | 10/22/21 11:30 AM | SC Paderborn 07 | Hamburger SV | 1-2 | 2 - 4 points |
| 10/23/21 6:30 AM | 10/23/21 6:30 AM | 1. FC Nürnberg | 1. FC Heidenheim 1846 | 4-0 | 2 - 4 points |
| 10/23/21 6:30 AM | 10/23/21 6:30 AM | Holstein Kiel | SV Darmstadt 98 | 1-1 | 2 - 4 points |
| 10/23/21 6:30 AM | 10/23/21 6:30 AM | Fortuna Düsseldorf | Karlsruher SC | 3-1 | 2 - 4 points |
| 10/23/21 1:30 PM | 10/23/21 1:30 PM | FC Schalke 04 | Dynamo Dresden | 3-0 | 2 - 4 points |
| 10/24/21 6:30 AM | 10/24/21 6:30 AM | FC St. Pauli | FC Hansa Rostock | 4-0 | 2 - 4 points |
| 10/24/21 6:30 AM | 10/24/21 6:30 AM | Jahn Regensburg | Hannover 96 | 3-1 | 2 - 4 points |
| 10/24/21 6:30 AM | 10/24/21 6:30 AM | SV Sandhausen | Werder Bremen | 2-2 | 2 - 4 points |