Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/15/21 11:30 AM | 10/15/21 11:30 AM | SC Paderborn 07 | Jahn Regensburg | 1-1 | 2 - 4 points |
| 10/15/21 11:30 AM | 10/15/21 11:30 AM | Hannover 96 | FC Schalke 04 | 0-1 | 2 - 4 points |
| 10/16/21 6:30 AM | 10/16/21 6:30 AM | 1. FC Heidenheim 1846 | FC St. Pauli | 2-4 | 2 - 4 points |
| 10/16/21 6:30 AM | 10/16/21 6:30 AM | FC Ingolstadt | Holstein Kiel | 1-1 | 2 - 4 points |
| 10/16/21 6:30 AM | 10/16/21 6:30 AM | Karlsruher SC | Erzgebirge Aue | 2-1 | 2 - 4 points |
| 10/16/21 1:30 PM | 10/16/21 1:30 PM | Hamburger SV | Fortuna Düsseldorf | 1-1 | 2 - 4 points |
| 10/17/21 6:30 AM | 10/17/21 6:30 AM | SV Darmstadt 98 | Werder Bremen | 3-0 | 2 - 4 points |
| 10/17/21 6:30 AM | 10/17/21 6:30 AM | Dynamo Dresden | 1. FC Nürnberg | 0-1 | 2 - 4 points |
| 10/17/21 6:30 AM | 10/17/21 6:30 AM | FC Hansa Rostock | SV Sandhausen | 1-1 | 2 - 4 points |