Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/22/22 11:30 AM | 4/22/22 11:30 AM | Fortuna Düsseldorf | Dynamo Dresden | 2-2 | 2 - 4 points |
| 4/22/22 11:30 AM | 4/22/22 11:30 AM | Karlsruher SC | FC Ingolstadt | 2-2 | 2 - 4 points |
| 4/23/22 6:30 AM | 4/23/22 6:30 AM | FC Schalke 04 | Werder Bremen | 1-4 | 2 - 4 points |
| 4/23/22 6:30 AM | 4/23/22 6:30 AM | Holstein Kiel | 1. FC Heidenheim 1846 | 1-1 | 2 - 4 points |
| 4/23/22 6:30 AM | 4/23/22 6:30 AM | Jahn Regensburg | Hamburger SV | 2-4 | 2 - 4 points |
| 4/23/22 1:30 PM | 4/23/22 1:30 PM | FC St. Pauli | SV Darmstadt 98 | 1-2 | 2 - 4 points |
| 4/24/22 6:30 AM | 4/24/22 6:30 AM | SC Paderborn 07 | Hannover 96 | 3-0 | 2 - 4 points |
| 4/24/22 6:30 AM | 4/24/22 6:30 AM | 1. FC Nürnberg | SV Sandhausen | 2-4 | 2 - 4 points |
| 4/24/22 6:30 AM | 4/24/22 6:30 AM | Erzgebirge Aue | FC Hansa Rostock | 2-2 | 2 - 4 points |