Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/1/22 11:30 AM | 4/1/22 11:30 AM | Dynamo Dresden | FC Schalke 04 | 1-2 | 2 - 4 points |
| 4/1/22 11:30 AM | 4/1/22 11:30 AM | FC Ingolstadt | Erzgebirge Aue | 3-2 | 2 - 4 points |
| 4/2/22 6:30 AM | 4/2/22 6:30 AM | Hamburger SV | SC Paderborn 07 | 1-2 | 2 - 4 points |
| 4/2/22 6:30 AM | 4/2/22 6:30 AM | SV Darmstadt 98 | Holstein Kiel | 3-1 | 2 - 4 points |
| 4/2/22 6:30 AM | 4/2/22 6:30 AM | Hannover 96 | Jahn Regensburg | 1-1 | 2 - 4 points |
| 4/2/22 1:30 PM | 4/2/22 1:30 PM | FC Hansa Rostock | FC St. Pauli | 1-0 | 2 - 4 points |
| 4/3/22 6:30 AM | 4/3/22 6:30 AM | Werder Bremen | SV Sandhausen | 1-1 | 2 - 4 points |
| 4/3/22 6:30 AM | 4/3/22 6:30 AM | Karlsruher SC | Fortuna Düsseldorf | 2-2 | 2 - 4 points |
| 4/3/22 6:30 AM | 4/3/22 6:30 AM | 1. FC Heidenheim 1846 | 1. FC Nürnberg | 3-1 | 2 - 4 points |