| Date | Dead line | Home | Away | Result | Points rule |
|---|
| 10/22/21 1:30 PM | 10/22/21 1:00 PM | FSV Mainz 05 | FC Augsburg | 4-1 | 2 - 4 points |
| 10/23/21 8:30 AM | 10/23/21 8:00 AM | RB Leipzig | SpVgg Greuther Fürth | 4-1 | 2 - 4 points |
| 10/23/21 8:30 AM | 10/23/21 8:00 AM | FC Bayern Munich | 1899 Hoffenheim | 4-0 | 2 - 4 points |
| 10/23/21 8:30 AM | 10/23/21 8:00 AM | Arminia Bielefeld | Borussia Dortmund | 1-3 | 2 - 4 points |
| 10/23/21 8:30 AM | 10/23/21 8:00 AM | VfL Wolfsburg | SC Freiburg | 0-2 | 2 - 4 points |
| 10/23/21 11:30 AM | 10/23/21 11:00 AM | Hertha BSC | Bor. Mönchengladbach | 1-0 | 2 - 4 points |
| 10/24/21 8:30 AM | 10/24/21 8:00 AM | 1. FC Köln | Bayer 04 Leverkusen | 2-2 | 2 - 4 points |
| 10/24/21 10:30 AM | 10/24/21 10:00 AM | VfB Stuttgart | 1. FC Union Berlin | 1-1 | 2 - 4 points |
| 10/24/21 12:30 PM | 10/24/21 12:00 PM | VfL Bochum | Eintracht Frankfurt | 2-0 | 2 - 4 points |
