| Date | Dead line | Home | Away | Result | Points rule |
|---|
| 9/17/21 1:30 PM | 9/17/21 1:00 PM | Hertha BSC | SpVgg Greuther Fürth | 2-1 | 2 - 4 points |
| 9/18/21 8:30 AM | 9/18/21 8:00 AM | FC Bayern Munich | VfL Bochum | 7-0 | 2 - 4 points |
| 9/18/21 8:30 AM | 9/18/21 8:00 AM | Arminia Bielefeld | 1899 Hoffenheim | 0-0 | 2 - 4 points |
| 9/18/21 8:30 AM | 9/18/21 8:00 AM | FC Augsburg | Bor. Mönchengladbach | 1-0 | 2 - 4 points |
| 9/18/21 8:30 AM | 9/18/21 8:00 AM | FSV Mainz 05 | SC Freiburg | 0-0 | 2 - 4 points |
| 9/18/21 11:30 AM | 9/18/21 11:00 AM | 1. FC Köln | RB Leipzig | 1-1 | 2 - 4 points |
| 9/19/21 8:30 AM | 9/19/21 8:00 AM | VfB Stuttgart | Bayer 04 Leverkusen | 1-3 | 2 - 4 points |
| 9/19/21 10:30 AM | 9/19/21 10:00 AM | Borussia Dortmund | 1. FC Union Berlin | 4-2 | 2 - 4 points |
| 9/19/21 12:30 PM | 9/19/21 12:00 PM | VfL Wolfsburg | Eintracht Frankfurt | 1-1 | 2 - 4 points |
