| Date | Dead line | Home | Away | Result | Points rule |
|---|
| 1/21/22 1:30 PM | 1/21/22 1:00 PM | Eintracht Frankfurt | Arminia Bielefeld | 0-2 | 2 - 4 points |
| 1/22/22 8:30 AM | 1/22/22 8:00 AM | Bor. Mönchengladbach | 1. FC Union Berlin | 1-2 | 2 - 4 points |
| 1/22/22 8:30 AM | 1/22/22 8:00 AM | Bayer 04 Leverkusen | FC Augsburg | 5-1 | 2 - 4 points |
| 1/22/22 8:30 AM | 1/22/22 8:00 AM | 1899 Hoffenheim | Borussia Dortmund | 2-3 | 2 - 4 points |
| 1/22/22 8:30 AM | 1/22/22 8:00 AM | SC Freiburg | VfB Stuttgart | 2-0 | 2 - 4 points |
| 1/22/22 8:30 AM | 1/22/22 8:00 AM | SpVgg Greuther Fürth | FSV Mainz 05 | 2-1 | 2 - 4 points |
| 1/22/22 11:30 AM | 1/22/22 11:00 AM | VfL Bochum | 1. FC Köln | 2-2 | 2 - 4 points |
| 1/23/22 8:30 AM | 1/23/22 8:00 AM | RB Leipzig | VfL Wolfsburg | 2-0 | 2 - 4 points |
| 1/23/22 10:30 AM | 1/23/22 10:00 AM | Hertha BSC | FC Bayern Munich | 1-4 | 2 - 4 points |
