Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 10/6/22 11:45 AM | 10/6/22 11:45 AM | Sheriff Tiraspol | Real Sociedad | Group E | 0-2 | 5 - 7 points |
| 10/6/22 11:45 AM | 10/6/22 11:45 AM | Omonia Nicosia | Manchester United | Group E | 2-3 | 5 - 7 points |
| 10/6/22 11:45 AM | 10/6/22 11:45 AM | AS Monaco | Trabzonspor | Group H | 3-1 | 5 - 7 points |
| 10/6/22 11:45 AM | 10/6/22 11:45 AM | Red Star Belgrad | Ferencvaros Budapest | Group H | 4-1 | 5 - 7 points |
| 10/6/22 11:45 AM | 10/6/22 11:45 AM | HJK Helsinki | PFC Ludogorets Razgrad | Group C | 1-1 | 5 - 7 points |
| 10/6/22 11:45 AM | 10/6/22 11:45 AM | SK Sturm Graz | Lazio Rom | Group F | 0-0 | 5 - 7 points |
| 10/6/22 11:45 AM | 10/6/22 11:45 AM | FC Zürich | PSV Eindhoven | Group A | 1-5 | 5 - 7 points |
| 10/6/22 11:45 AM | 10/6/22 11:45 AM | Malmö FF | 1. FC Union Berlin | Group D | 0-1 | 5 - 7 points |
| 10/6/22 2:00 PM | 10/6/22 2:00 PM | AS Roma | Real Betis Sevilla | Group C | 1-2 | 5 - 7 points |
| 10/6/22 2:00 PM | 10/6/22 2:00 PM | FC Midtjylland | Feyenoord Rotterdam | Group F | 2-2 | 5 - 7 points |
| 10/6/22 2:00 PM | 10/6/22 2:00 PM | Stade Rennes | Dynamo Kiew | Group B | 2-1 | 5 - 7 points |
| 10/6/22 2:00 PM | 10/6/22 2:00 PM | Fenerbahce Istanbul | AEK Larnaka | Group B | 2-0 | 5 - 7 points |
| 10/6/22 2:00 PM | 10/6/22 2:00 PM | SC Freiburg | FC Nantes | Group G | 2-0 | 5 - 7 points |
| 10/6/22 2:00 PM | 10/6/22 2:00 PM | Olympiakos Piräus | Qarabag | Group G | 0-3 | 5 - 7 points |
| 10/6/22 2:00 PM | 10/6/22 2:00 PM | Arsenal FC | FK Bodö/Glimt | Group A | 3-0 | 5 - 7 points |
| 10/6/22 2:00 PM | 10/6/22 2:00 PM | Sporting Braga | Royale Union Saint-Gilloise | Group D | 1-2 | 5 - 7 points |