Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 9/8/22 11:45 AM | 9/8/22 11:45 AM | PFC Ludogorets Razgrad | AS Roma | Group C | 2-1 | 5 - 7 points |
| 9/8/22 11:45 AM | 9/8/22 11:45 AM | HJK Helsinki | Real Betis Sevilla | Group C | 0-2 | 5 - 7 points |
| 9/8/22 11:45 AM | 9/8/22 11:45 AM | AEK Larnaka | Stade Rennes | Group B | 1-2 | 5 - 7 points |
| 9/8/22 11:45 AM | 9/8/22 11:45 AM | Fenerbahce Istanbul | Dynamo Kiew | Group B | 2-1 | 5 - 7 points |
| 9/8/22 11:45 AM | 9/8/22 11:45 AM | PSV Eindhoven | FK Bodö/Glimt | Group A | 1-1 | 5 - 7 points |
| 9/8/22 11:45 AM | 9/8/22 11:45 AM | FC Zürich | Arsenal FC | Group A | 1-2 | 5 - 7 points |
| 9/8/22 11:45 AM | 9/8/22 11:45 AM | Malmö FF | Sporting Braga | Group D | 0-2 | 5 - 7 points |
| 9/8/22 11:45 AM | 9/8/22 11:45 AM | 1. FC Union Berlin | Royale Union Saint-Gilloise | Group D | 0-1 | 5 - 7 points |
| 9/8/22 2:00 PM | 9/8/22 2:00 PM | Red Star Belgrad | AS Monaco | Group H | 0-1 | 5 - 7 points |
| 9/8/22 2:00 PM | 9/8/22 2:00 PM | Ferencvaros Budapest | Trabzonspor | Group H | 3-2 | 5 - 7 points |
| 9/8/22 2:00 PM | 9/8/22 2:00 PM | Lazio Rom | Feyenoord Rotterdam | Group F | 4-2 | 5 - 7 points |
| 9/8/22 2:00 PM | 9/8/22 2:00 PM | SK Sturm Graz | FC Midtjylland | Group F | 1-0 | 5 - 7 points |
| 9/8/22 2:00 PM | 9/8/22 2:00 PM | FC Nantes | Olympiakos Piräus | Group G | 2-1 | 5 - 7 points |
| 9/8/22 2:00 PM | 9/8/22 2:00 PM | SC Freiburg | Qarabag | Group G | 2-1 | 5 - 7 points |
| 9/8/22 2:00 PM | 9/8/22 2:00 PM | Manchester United | Real Sociedad | Group E | 0-1 | 5 - 7 points |
| 9/8/22 2:00 PM | 9/8/22 2:00 PM | Omonia Nicosia | Sheriff Tiraspol | Group E | 0-3 | 5 - 7 points |