Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/29/21 12:00 PM | 5/29/21 12:00 PM | Chicago Fire | CF Montreal | 0-1 | 3 - 5 - 4 |
| 5/29/21 12:00 PM | 5/29/21 12:00 PM | New York Red Bulls | Orlando City | 2-1 | 3 - 5 - 4 |
| 5/29/21 2:00 PM | 5/29/21 2:00 PM | Columbus Crew | Toronto FC | 2-1 | 3 - 5 - 5 |
| 5/29/21 2:00 PM | 5/29/21 2:00 PM | Cincinnati FC | New England Revolution | 0-1 | 5 - 5 - 3 |
| 5/29/21 2:30 PM | 5/29/21 2:30 PM | Atlanta United FC | Nashville SC | 2-2 | 3 - 5 - 5 |
| 5/29/21 4:00 PM | 5/29/21 4:00 PM | Los Angeles FC | New York City FC | 1-2 | 3 - 5 - 5 |
| 5/29/21 6:00 PM | 5/29/21 6:00 PM | Los Angeles Galaxy | San Jose Earthquakes | 1-0 | 3 - 5 - 5 |
| 5/29/21 7:00 PM | 5/29/21 7:00 PM | Inter Miami CF | D.C. United | 0-3 | 3 - 5 - 5 |
| 5/29/21 7:30 PM | 5/29/21 7:30 PM | Sporting Kansas City | Houston Dynamo | 3-2 | 3 - 5 - 5 |
| 5/29/21 8:00 PM | 5/29/21 8:00 PM | Colorado Rapids | FC Dallas | 3-0 | 3 - 5 - 5 |
| 5/29/21 8:30 PM | 5/29/21 8:30 PM | Real Salt Lake | Minnesota United FC | 1-1 | 3 - 5 - 5 |
| 5/30/21 6:00 PM | 5/30/21 6:00 PM | Philadelphia Union | Portland Timbers | 3-0 | 4 - 4 - 4 |
| 5/30/21 8:30 PM | 5/30/21 8:30 PM | Seattle Sounders | Austin FC | 0-0 | 3 - 5 - 5 |