Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/22/21 12:00 PM | 5/22/21 12:00 PM | CF Montreal | Cincinnati FC | 1-2 | 3 - 5 - 5 |
| 5/22/21 2:30 PM | 5/22/21 2:30 PM | Portland Timbers | Los Angeles Galaxy | 3-0 | 4 - 5 - 4 |
| 5/22/21 5:00 PM | 5/22/21 5:00 PM | Chicago Fire | Inter Miami CF | 1-0 | 4 - 5 - 3 |
| 5/22/21 6:00 PM | 5/22/21 6:00 PM | Orlando City | Toronto FC | 1-0 | 3 - 5 - 5 |
| 5/22/21 6:30 PM | 5/22/21 6:30 PM | New York City FC | Columbus Crew | 1-2 | 3 - 5 - 5 |
| 5/22/21 7:00 PM | 5/22/21 7:00 PM | New England Revolution | New York Red Bulls | 3-1 | 4 - 5 - 4 |
| 5/22/21 7:00 PM | 5/22/21 7:00 PM | FC Dallas | Real Salt Lake | 2-2 | 4 - 5 - 4 |
| 5/22/21 8:00 PM | 5/22/21 8:00 PM | Houston Dynamo | Vancouver Whitecaps | 2-1 | 3 - 5 - 5 |
| 5/22/21 9:00 PM | 5/22/21 9:00 PM | San Jose Earthquakes | Sporting Kansas City | 1-3 | 4 - 5 - 4 |
| 5/22/21 9:30 PM | 5/22/21 9:30 PM | Los Angeles FC | Colorado Rapids | 2-1 | 3 - 5 - 5 |
| 5/23/21 3:30 PM | 5/23/21 3:30 PM | Seattle Sounders | Atlanta United FC | 1-1 | 3 - 5 - 5 |
| 5/23/21 6:15 PM | 5/23/21 6:15 PM | D.C. United | Philadelphia Union | 0-1 | 4 - 5 - 4 |
| 5/23/21 8:00 PM | 5/23/21 8:00 PM | Nashville SC | Austin FC | 1-0 | 3 - 5 - 5 |