Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/9/21 2:00 PM | 5/9/21 2:00 PM | Portland Timbers | Seattle Sounders | 1-2 | 5 - 5 - 3 |
| 5/12/21 6:00 PM | 5/12/21 6:00 PM | Toronto FC | Columbus Crew | 2-0 | 4 - 5 - 3 |
| 5/12/21 6:30 PM | 5/12/21 6:30 PM | Inter Miami CF | CF Montreal | 0-2 | 3 - 5 - 5 |
| 5/12/21 6:30 PM | 5/12/21 6:30 PM | Philadelphia Union | New England Revolution | 1-1 | 4 - 5 - 4 |
| 5/12/21 7:30 PM | 5/12/21 7:30 PM | Houston Dynamo | Sporting Kansas City | 1-0 | 3 - 5 - 4 |
| 5/12/21 8:00 PM | 5/12/21 8:00 PM | Minnesota United FC | Vancouver Whitecaps | 1-0 | 3 - 5 - 4 |
| 5/12/21 9:30 PM | 5/12/21 9:30 PM | San Jose Earthquakes | Seattle Sounders | 0-1 | 4 - 5 - 3 |
| 5/13/21 7:00 PM | 5/13/21 7:00 PM | D.C. United | Chicago Fire | 1-0 | 3 - 5 - 5 |
| 5/15/21 12:00 PM | 5/15/21 12:00 PM | New York City FC | Toronto FC | 1-1 | 3 - 5 - 5 |
| 5/15/21 2:30 PM | 5/15/21 2:30 PM | Los Angeles Galaxy | Austin FC | 2-0 | 3 - 5 - 5 |
| 5/15/21 6:00 PM | 5/15/21 6:00 PM | Atlanta United FC | CF Montreal | 1-0 | 3 - 5 - 5 |
| 5/15/21 6:30 PM | 5/15/21 6:30 PM | Philadelphia Union | New York Red Bulls | 1-0 | 3 - 5 - 4 |
| 5/15/21 7:00 PM | 5/15/21 7:00 PM | Minnesota United FC | FC Dallas | 1-0 | 3 - 5 - 4 |
| 5/15/21 8:00 PM | 5/15/21 8:00 PM | Colorado Rapids | Houston Dynamo | 3-1 | 3 - 5 - 4 |
| 5/15/21 8:30 PM | 5/15/21 8:30 PM | Real Salt Lake | Nashville SC | 0-0 | 3 - 5 - 5 |
| 5/15/21 9:00 PM | 5/15/21 9:00 PM | San Jose Earthquakes | Portland Timbers | 0-2 | 4 - 5 - 4 |
| 5/16/21 1:00 PM | 5/16/21 1:00 PM | Sporting Kansas City | Vancouver Whitecaps | 3-0 | 3 - 5 - 5 |
| 5/16/21 3:00 PM | 5/16/21 3:00 PM | Cincinnati FC | Inter Miami CF | 2-3 | 5 - 5 - 3 |
| 5/16/21 5:00 PM | 5/16/21 5:00 PM | New England Revolution | Columbus Crew | 1-0 | 3 - 5 - 4 |
| 5/16/21 7:00 PM | 5/16/21 7:00 PM | D.C. United | Orlando City | 0-1 | 3 - 5 - 4 |
| 5/16/21 8:30 PM | 5/16/21 8:30 PM | Seattle Sounders | Los Angeles FC | 2-0 | 3 - 5 - 5 |