Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/7/21 8:30 PM | 5/7/21 8:30 PM | Real Salt Lake | San Jose Earthquakes | 1-2 | 3 - 5 - 5 |
| 5/8/21 12:00 PM | 5/8/21 12:00 PM | New York Red Bulls | Toronto FC | 2-0 | 3 - 5 - 5 |
| 5/8/21 12:00 PM | 5/8/21 12:00 PM | Chicago Fire | Philadelphia Union | 0-2 | 4 - 5 - 4 |
| 5/8/21 12:30 PM | 5/8/21 12:30 PM | Columbus Crew | D.C. United | 3-1 | 3 - 5 - 5 |
| 5/8/21 12:30 PM | 5/8/21 12:30 PM | Nashville SC | New England Revolution | 2-0 | 4 - 5 - 4 |
| 5/8/21 2:00 PM | 5/8/21 2:00 PM | Vancouver Whitecaps | CF Montreal | 2-0 | 4 - 5 - 3 |
| 5/8/21 2:30 PM | 5/8/21 2:30 PM | FC Dallas | Houston Dynamo | 1-1 | 3 - 5 - 5 |
| 5/8/21 5:00 PM | 5/8/21 5:00 PM | Orlando City | New York City FC | 1-1 | 4 - 5 - 4 |
| 5/8/21 7:00 PM | 5/8/21 7:00 PM | Los Angeles Galaxy | Los Angeles FC | 2-1 | 3 - 5 - 4 |
| 5/8/21 9:00 PM | 5/8/21 9:00 PM | Colorado Rapids | Minnesota United FC | 3-2 | 3 - 5 - 5 |
| 5/9/21 12:00 PM | 5/9/21 12:00 PM | Inter Miami CF | Atlanta United FC | 1-1 | 3 - 5 - 4 |
| 5/9/21 6:30 PM | 5/9/21 6:30 PM | Sporting Kansas City | Austin FC | 2-1 | 3 - 5 - 5 |