Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/20/21 1:30 PM | 11/20/21 1:30 PM | Philadelphia Union | New York Red Bulls | 1-0a.e.t | 3 - 5 - 4 |
| 11/20/21 4:00 PM | 11/20/21 4:00 PM | Sporting Kansas City | Vancouver Whitecaps | 3-1 | 3 - 5 - 5 |
| 11/21/21 2:00 PM | 11/21/21 2:00 PM | New York City FC | Atlanta United FC | 2-0 | 3 - 5 - 5 |
| 11/21/21 4:30 PM | 11/21/21 4:30 PM | Portland Timbers | Minnesota United FC | 3-1 | 3 - 5 - 4 |
| 11/23/21 7:00 PM | 11/23/21 7:00 PM | Nashville SC | Orlando City | 3-1 | 3 - 5 - 5 |
| 11/23/21 9:30 PM | 11/23/21 9:30 PM | Seattle Sounders | Real Salt Lake | 5-6a.PSO | 3 - 5 - 5 |