Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/16/21 12:00 PM | 10/16/21 12:00 PM | CF Montreal | Philadelphia Union | 2-2 | 3 - 5 - 4 |
| 10/16/21 2:30 PM | 10/16/21 2:30 PM | Los Angeles FC | San Jose Earthquakes | 3-1 | 3 - 5 - 5 |
| 10/16/21 5:00 PM | 10/16/21 5:00 PM | Columbus Crew | Inter Miami CF | 4-0 | 3 - 5 - 5 |
| 10/16/21 6:00 PM | 10/16/21 6:00 PM | New England Revolution | Chicago Fire | 2-2 | 3 - 5 - 5 |
| 10/16/21 6:30 PM | 10/16/21 6:30 PM | D.C. United | Nashville SC | 0-0 | 3 - 5 - 5 |
| 10/16/21 6:30 PM | 10/16/21 6:30 PM | Cincinnati FC | Orlando City | 0-1 | 5 - 5 - 3 |
| 10/16/21 6:30 PM | 10/16/21 6:30 PM | Toronto FC | Atlanta United FC | 0-2 | 3 - 5 - 4 |
| 10/16/21 7:30 PM | 10/16/21 7:30 PM | Houston Dynamo | Seattle Sounders | 2-1 | 5 - 5 - 3 |
| 10/16/21 8:00 PM | 10/16/21 8:00 PM | Austin FC | Minnesota United FC | 0-1 | 4 - 5 - 4 |
| 10/16/21 8:30 PM | 10/16/21 8:30 PM | Real Salt Lake | Colorado Rapids | 3-1 | 3 - 5 - 4 |
| 10/16/21 9:30 PM | 10/16/21 9:30 PM | Los Angeles Galaxy | Portland Timbers | 2-1 | 4 - 5 - 4 |
| 10/17/21 12:00 PM | 10/17/21 12:00 PM | New York Red Bulls | New York City FC | 1-0 | 3 - 5 - 4 |
| 10/17/21 9:00 PM | 10/17/21 9:00 PM | Vancouver Whitecaps | Sporting Kansas City | 2-1 | 4 - 5 - 4 |